Time medicine

What will be a representative medical application of time control medicine? Sleep-wake cycles are profoundly influenced by the abnormalities of the circadian clock. We have recently demonstrated that Gpr176 is an orphan G-protein-coupled receptor that sets the pace of the central clock in the brain. Gpr176 is thus a potential drug target to treat sleep-wake cycle dysfunction. Development of a chemical modulator of Gpr176 function is our next on-going challenge.
See: Doi et al Nature Commun, 2016; Wang et al Sci Rep, 2020; Nakagawa et al IJMS, 2020