Paradigm shift of clock disorders

One of the most significant conceptual changes brought about by the analysis of circadian clock-deficient mice is that abnormalities in the circadian clock are linked not only to sleep arousal disorder but also to a wide variety of common diseases, including hypertension, diabetes, obesity, and cancer. Our lab previously revealed a molecular mechanism linking circadian malfunction to salt-sensitive hypertension. Elucidation of clock dysfunction behind diseases will continue to be a main project of our team. 
See: Doi et al Nature Med, 2010; Negoro et al Nature Commun, 2012; Chao et al Nature Commun, 2017