Strategies for circadian therapy

The development of anti-cancer drugs and therapies for lifestyle-related illnesses, such as cardiovascular disorder, obesity, and diabetes mellitus, would not solely involve manipulation of the core clock proteins per se, but will also be equally facilitated through the manipulation of the function of the group called “output” genes, which are regulated by the circadian clock. Manipulating the “input” signals that adjust the phase and amplitude of the circadian clock will also expand the path to drug discovery for clock-related disorders.
See: Doi et al J Clin Endocrinol Metab, 2014; Ota et al Mol Cell Biol, 2014